The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2016
Filed:
Jun. 02, 2011
Sergey Balashov, Hamilton, NJ (US);
Eli Mordechai, Robbinsville, NJ (US);
Martin E. Adelson, East Windsor, NJ (US);
Scott E. Gygax, Yardley, PA (US);
Sergey Balashov, Hamilton, NJ (US);
Eli Mordechai, Robbinsville, NJ (US);
Martin E. Adelson, East Windsor, NJ (US);
Scott E. Gygax, Yardley, PA (US);
Medical Diagnostic Laboratories, LLC, Hamilton, NJ (US);
Abstract
The present invention relates to an antibiotic resistance profile forby assessing the presence of mutations (e.g., SNP) in antibiotic resistant genes that confer bacterial resistance against antibiotics such as penicillin, tetracycline, fluoroquinolones, cephalosporin, macrolides and spectinomycin. There is provided a method and a kit for generating an antibiotic resistance profile forby utilizing a multiplex PCR to amplify segments of antibiotic-resistant genes, allele-specific primer extension to detect gene mutation, and detection of such gene mutations with gel electrophoresis, capillary electrophoresis, or DNA microarray. The present method provides useful information to physicians relating the antibiotic susceptibility ofagainst different classes of antibiotics. Relying on this personalized diagnostic tool, physicians can better inform about antibiotic susceptibility and thereby open up medical intervention avenues for treatingwith antibiotics. There is provided a therapeutic application of the antibiotic resistance profile that has advantages of: (i) providing a more effective regime for gonorrhea treatment; and (ii) halting the evolutionary pressures towards antibiotic resistance in thetherapy.