The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2016
Filed:
Jul. 01, 2005
Applicant:
Hui Wang, Loveland, CO (US);
Inventor:
Hui Wang, Loveland, CO (US);
Assignee:
AGILENT TECHNOLOGIES, INC, Santa Clara, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/34 (2006.01); C12Q 1/68 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); G01N 31/22 (2006.01); G01N 33/52 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6837 (2013.01); C12Q 1/6837 (2013.01); C12Q 2525/301 (2013.01);
Abstract
The invention provides a nucleic acid probe for detecting a polynucleotide. The probe contains a region that base-pairs with a polynucleotide to form a duplex and a Tenhancement domain that increases the stability of the duplex. The Tenhancement domain may contain a nucleotide clamp and/or a hairpin structure, for example. Also provided is an array of subject nucleic acid probes bound to a surface of the solid support. Methods of using a subject probe to assess polynucleotides, e.g., small RNAs in a sample are provided, as are kits for use in practicing the subject methods.