The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2016
Filed:
Oct. 12, 2012
Feng Cong, Quincy, MA (US);
Huaixiang Hao, Malden, MA (US);
Lloyd B. Klickstein, Newton, MA (US);
Rou-fun Kwong, Westford, MA (US);
Ann Taylor, Wickford, RI (US);
Yang Xie, Quincy, MA (US);
Feng Cong, Quincy, MA (US);
Huaixiang Hao, Malden, MA (US);
Lloyd B. Klickstein, Newton, MA (US);
Rou-Fun Kwong, Westford, MA (US);
Ann Taylor, Wickford, RI (US);
Yang Xie, Quincy, MA (US);
NOVARTIS AG, Basel, CH;
Abstract
The transmembrane E3 ubiquitin ligases ZNRF3 and RNF43 are negative regulators of β-catenin and the Wnt signaling pathway in eukaryotic cells. The activity of ZNRF3 can be modulated by antibody binding to its extracellular domain, thus causing an increase in Wnt signaling. The ZNRF3 antagonizing antibodies can be used to treat diseases with low Wnt signaling, such as short bowel syndrome, osteoporosis, diabetes, neurodegenerative diseases, and mucositis. In addition, the antagonizing antibodies of the invention can be used to enhance Wnt signaling for tissue repair and wound healing.