The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 29, 2016

Filed:

Nov. 07, 2013
Applicant:

E.r. Squibb & Sons, L.l.c., Princeton, NJ (US);

Inventors:

Alan J. Korman, Piedmont, CA (US);

Mark J. Selby, San Francisco, CA (US);

Li-Sheng Lu, Mountain View, CA (US);

Alison J. Witte, Scotts Valley, CA (US);

Haichun Huang, Fremont, CA (US);

Assignee:

E.R. SQUIBB & SONS, L.L.C., Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/00 (2006.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); C07K 16/2827 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/41 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C07K 2319/55 (2013.01);
Abstract

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.


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