The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2016
Filed:
Oct. 01, 2013
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Elizabeth Jaffee, Lutherville, MD (US);
Ralph Hruban, Baltimore, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/00 (2006.01); A61K 39/385 (2006.01); C07K 14/00 (2006.01); C07K 7/06 (2006.01); A61K 39/00 (2006.01); C07K 16/30 (2006.01); C12N 15/85 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01); A61K 39/0011 (2013.01); C07K 16/30 (2013.01); C12N 15/8509 (2013.01); A01K 2267/0331 (2013.01); A61K 2039/505 (2013.01); A61K 2039/522 (2013.01); A61K 2039/523 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55522 (2013.01); A61K 2039/6031 (2013.01); C07K 14/4748 (2013.01); C12N 2710/16522 (2013.01); C12N 2740/13043 (2013.01);
Abstract
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line.