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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9296734 B1

PDFFull Text
Date of Patent:
Mar. 29, 2016

Filed:

Feb. 27, 2014

Perfluorinated 5,6-dihydro-4h-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use

Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Ana Elena Minatti, Santa Monica, CA (US);

Jonathan D. Low, Tarzana, CA (US);

Jennifer R. Allen, Newbury Park, CA (US);

Jian Chen, Camarillo, CA (US);

Ning Chen, Thousand Oaks, CA (US);

Yuan Cheng, Newbury Park, CA (US);

Ted Judd, Granada Hills, CA (US);

Qingyian Liu, Camarillo, CA (US);

Patricia Lopez, Woodland Hills, CA (US);

Wenyuan Qian, Newbury Park, CA (US);

Shannon Rumfelt, Camarillo, CA (US);

Robert M. Rzasa, Ventura, CA (US);

Nuria A. Tamayo, Newbury Park, CA (US);

Qiufen Xue, Newbury Park, CA (US);

Bryant Yang, Agoura Hills, CA (US);

Wenge Zhong, Thousand Oaks, CA (US);

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorneys:

G. Prabhaker Reddy

Bernard P. Friedrichsen

Markus Bergauer

Primary Examiner:

Kahsay Habte

Int. Cl.
CPC ...
C07D 413/14 (2006.01); C07D 413/12 (2006.01); C07D 471/04 (2006.01); C07D 513/04 (2006.01); C07F 7/08 (2006.01); C07D 413/04 (2006.01); C07D 413/10 (2006.01); C07D 265/08 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 413/14 (2013.01); C07D 265/08 (2013.01); C07D 413/04 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01); C07D 513/04 (2013.01); C07F 7/0812 (2013.01);
Abstract

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, A, A, A, each of Rand R, Rand Rof Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.

Find Patent Forward Citations

Minatti, Ana. (2016). Perfluorinated 5,6-dihydro-4h-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use (U.S. Patent No. 9296734). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9296734

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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