The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2016
Filed:
Feb. 26, 2014
Bracco Suisse SA, Manno, CH;
Philippe Bussat, Pers-Jussy, FR;
Samir Cherkaoui, Feigeres, FR;
Hong (Helen) Fan, Shanghai, CN;
Bernard Lamy, Saint-Julien-en-Genevois, FR;
Palaniappa Nanjappan, Princeton, NJ (US);
Radhakrishna K. Pillai, Cranbury, NJ (US);
Sibylle Pochon, Troinex, CH;
Bo Song, Princeton, NJ (US);
Rolf E. Swenson, Princeton, NJ (US);
BRACCO SUISSE SA, Manno, CH;
Abstract
Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.