The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2016
Filed:
Aug. 03, 2010
Ugur Sahin, Mainz, DE;
Andreas Kuhn, Mainz, DE;
Edward Darzynkiewicz, Izabelin-Hornowek, PL;
Jacek Jemielity, Warsaw, PL;
Joanna Kowalska, Radom, PL;
Ugur Sahin, Mainz, DE;
Andreas Kuhn, Mainz, DE;
Edward Darzynkiewicz, Izabelin-Hornowek, PL;
Jacek Jemielity, Warsaw, PL;
Joanna Kowalska, Radom, PL;
BIONTECH AG, Mainz, DE;
UNIWERSYTET WARSZAWSKI, Warszawa, PL;
Abstract
The present invention relates to modification of RNA with 5'-cap analogs of Formula (1): wherein R-Rand n are as described herein, in order to improve the stability and increase the expression of said RNA, in particular in immature antigen presenting cells. The present invention provides a vaccine composition comprising said stabilized RNA, immature antigen presenting cells comprising said stabilized RNA, and methods for stimulating and/or activating immune effector cells and for inducing an immune response in an individual using said stabilized RNA.