The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2016
Filed:
Nov. 04, 2010
Applicant:
Junying Yu, Middleton, WI (US);
Inventor:
Junying Yu, Middleton, WI (US);
Assignee:
Cellular Dynamics International, Inc., Madison, WI (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/10 (2006.01); C12N 5/071 (2010.01); A61K 35/545 (2015.01); A61P 25/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/545 (2013.01); C12N 2501/115 (2013.01); C12N 2501/15 (2013.01); C12N 2501/235 (2013.01); C12N 2501/60 (2013.01); C12N 2501/70 (2013.01); C12N 2510/00 (2013.01);
Abstract
Methods and composition of induction of pluripotent stem cells are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells with cell signaling regulators are described. Furthermore, certain aspects of the invention provide novel compositions comprising induced pluripotent stem cells essentially free of exogenous retroviral vector elements in the presence of a medium comprising signaling inhibitors. In certain aspects, feeder-free episomal reprogramming methods may be provided.