The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 22, 2016

Filed:

May. 11, 2012
Applicants:

Salim Merali, Bryn Mawr, PA (US);

Camilo Moncada, Philadelphia, PA (US);

Steven G. Kelsen, Rydal, PA (US);

Carlos A. Barrero, Philadelphia, PA (US);

Oscar Mauricio Perez Leal, Barranquilla, CO (US);

Inventors:

Salim Merali, Bryn Mawr, PA (US);

Camilo Moncada, Philadelphia, PA (US);

Steven G. Kelsen, Rydal, PA (US);

Carlos A. Barrero, Philadelphia, PA (US);

Oscar Mauricio Perez Leal, Barranquilla, CO (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/00 (2006.01); G01N 33/577 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/577 (2013.01); G01N 33/6875 (2013.01); G01N 2440/12 (2013.01); G01N 2800/122 (2013.01);
Abstract

Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.


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