The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 22, 2016

Filed:

Oct. 25, 2010
Applicants:

Dimitri Semizarov, Chicago, IL (US);

Xin LU, Libertyville, IL (US);

KE Zhang, Grand Forks, ND (US);

Rick R. Lesniewski, Collegeville, PA (US);

John S. Coon, Oak Park, IL (US);

Inventors:

Dimitri Semizarov, Chicago, IL (US);

Xin Lu, Libertyville, IL (US);

Ke Zhang, Grand Forks, ND (US);

Rick R. Lesniewski, Collegeville, PA (US);

John S. Coon, Oak Park, IL (US);

Assignee:

Abbott Laboratories, Abbott Park, IL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57423 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/178 (2013.01); G01N 2800/52 (2013.01); G01N 2800/54 (2013.01); G01N 2800/56 (2013.01); G01N 2800/60 (2013.01);
Abstract

The present disclosure provides methods for identifying early stage non-small-cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after surgical resection. The methods are based in part on the discovery of chromosomal copy number abnormalities that can be used for prognostic classification. The methods preferably use fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of these genetic loci.


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