The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2016
Filed:
Jan. 18, 2006
Alfred Hahn, Mannheim, DE;
Ralf Loebbert, Speyer, DE;
Nicole Teusch, Wülfrath, DE;
Achim Möller, Grunstadt, DE;
Ulrich Ebert, Ludwigshafen, DE;
Martin Schmidt, Benshelm, DE;
Alfred Hahn, Mannheim, DE;
Ralf Loebbert, Speyer, DE;
Nicole Teusch, Wülfrath, DE;
Achim Möller, Grunstadt, DE;
Ulrich Ebert, Ludwigshafen, DE;
Martin Schmidt, Benshelm, DE;
AbbVie Deutschland GmbH & Co. KG, Wiesbaden, DE;
Abstract
The present invention relates to the identification, functionality and use of domains from the N terminus of the receptor for Advanced Glycation End Products (AGER). These domains, called receptor multimerization epitope (RME), are highly conserved in all AGER protein sequences. They represent the mediators for AGER self-association and heteromerization with other proteins. The invention likewise relates to the identification, functionality and use of peptides derived from the C domain of AGER (AGER-CDP). The AGER RMEs and AGER-CDPs of the invention are suitable as target for identifying AGER ligands which modulate the natural ligand interaction; as immunogen for active or passive immunization of individuals, as diagnostic means for identifying immunogenic reactions, and as peptide ligands for modulating protein-protein interactions involving AGER.