The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2016
Filed:
Sep. 14, 2011
Kallanthottathil G. Rajeev, Cambridge, MA (US);
Tracy Zimmermann, Cambridge, MA (US);
Muthiah Manoharan, Cambridge, MA (US);
Martin Maier, Cambridge, MA (US);
Kevin Fitzgerald, Cambridge, MA (US);
Kallanthottathil G. Rajeev, Cambridge, MA (US);
Tracy Zimmermann, Cambridge, MA (US);
Muthiah Manoharan, Cambridge, MA (US);
Martin Maier, Cambridge, MA (US);
Kevin Fitzgerald, Cambridge, MA (US);
ALNYLAM PHARMACEUTICALS, INC., Cambridge, MA (US);
Abstract
The present invention provides effective motifs for RNA agents conjugated to at least one ligand, which are advantageous for the in vivo delivery of iRNA duplex agents. Additionally, the present invention provides methods of making these compositions, as well as methods of introducing these iRNA duplex agents into cells using these compositions, e.g., for the treatment of various disease conditions.