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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9290757 B1

PDFFull Text
Date of Patent:
Mar. 22, 2016

Filed:

May. 18, 2012

Protease screening methods and proteases identified thereby

Applicant:

Edwin L. Madison, San Francisco, CA (US);

Inventor:

Edwin L. Madison, San Francisco, CA (US);

Assignee:

Catalyst Biosciences, Inc., South San Francisco, CA (US);

Attorneys:

Dentons US LLP

Stephanie Seidman

Primary Examiner:

Manjunath Rao

Assistant Examiner:

William W Moore

Int. Cl.
CPC ...
C12N 9/64 (2006.01); A61K 38/00 (2006.01); C12Q 1/37 (2006.01); G01N 33/68 (2006.01); C12N 15/10 (2006.01); C12N 9/50 (2006.01); C12N 9/72 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1037 (2013.01); C12N 9/50 (2013.01); C12N 9/6408 (2013.01); C12N 9/6462 (2013.01); C12Q 1/37 (2013.01); C12Y 304/21073 (2013.01); C12Y 304/21109 (2013.01); G01N 33/6842 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/21 (2013.01); C07K 2319/23 (2013.01); C07K 2319/30 (2013.01); C07K 2319/41 (2013.01); C07K 2319/42 (2013.01);
Abstract

Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.

Find Patent Forward Citations

Madison, Edwin. (2016). Protease screening methods and proteases identified thereby (U.S. Patent No. 9290757). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9290757

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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