The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2016
Filed:
May. 18, 2012
Applicant:
Edwin L. Madison, San Francisco, CA (US);
Inventor:
Edwin L. Madison, San Francisco, CA (US);
Assignee:
Catalyst Biosciences, Inc., South San Francisco, CA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/64 (2006.01); A61K 38/00 (2006.01); C12Q 1/37 (2006.01); G01N 33/68 (2006.01); C12N 15/10 (2006.01); C12N 9/50 (2006.01); C12N 9/72 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1037 (2013.01); C12N 9/50 (2013.01); C12N 9/6408 (2013.01); C12N 9/6462 (2013.01); C12Q 1/37 (2013.01); C12Y 304/21073 (2013.01); C12Y 304/21109 (2013.01); G01N 33/6842 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/21 (2013.01); C07K 2319/23 (2013.01); C07K 2319/30 (2013.01); C07K 2319/41 (2013.01); C07K 2319/42 (2013.01);
Abstract
Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.