The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2016
Filed:
Sep. 17, 2013
Thomas Weimer, Gladenbach, DE;
Stefan Schulte, Marburg, DE;
Hubert Metzner, Marburg, DE;
Ulrich Kronthaler, Deisenhofen, DE;
Holger Lind, Marburg, DE;
Wiegand Lang, Colbe, DE;
Thomas Weimer, Gladenbach, DE;
Stefan Schulte, Marburg, DE;
Hubert Metzner, Marburg, DE;
Ulrich Kronthaler, Deisenhofen, DE;
Holger Lind, Marburg, DE;
Wiegand Lang, Colbe, DE;
CSL Behring GmbH, Marburg, DE;
Abstract
The present invention relates to modified nucleic acid sequences coding for coagulation factor VIII (FVIII) and for von Willebrand factor (VWF) as well as complexes thereof and their derivatives, recombinant expression vectors containing such nucleic acid sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives coded for by said nucleic acid sequences which recombinant polypeptides and derivatives do have biological activities together with prolonged in vivo half-life and/or improved in vivo recovery compared to the unmodified wild-type protein. The invention also relates to corresponding FVIII sequences that result in improved expression yield. The present invention further relates to processes for the manufacture of such recombinant proteins and their derivatives. The invention also relates to a transfer vector for use in human gene therapy, which comprises such modified nucleic acid sequences.