The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2016
Filed:
Oct. 24, 2012
Ustav Organicke Chemie a Biochemie Akademie Ved Ceske Republiky, V.v.i., Prague, CZ;
Ustav Molekularni Genetiky Akademie Ved Ceske Republiky, V.v.i., Prague, CZ;
Ustav Anorganicke Chemie Akademie Ved Ceske Republiky, V.v.i., Husinec-Rez, CZ;
Univerzita Palackeho V Olomouci, Olomouc, CZ;
Jiri Brynda, Prague, CZ;
Petr Cigler, Prague, CZ;
Bohumir Gruner, Brandysek, CZ;
Pavlina Maloy Rezacova, Velvary, CZ;
Pavel Mader, Prague, CZ;
Vaclav Sicha, Prague, CZ;
Mario Bakardjiev, Prague, CZ;
Josef Holub, Prague, CZ;
Petr Dzubak, Brodek u Prerova, CZ;
Marian Hajduch, Moravsky Beraun, CZ;
USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY, V.V.I., Prague, CZ;
USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY, V.V.I., Prague, CZ;
USTAV ANORGANICKE CHEMIE AKADEMIE VED CESKE REPUBLIKY, V.V.I., Husinec-Rez, CZ;
UNIVERZITA PALACKEHO V OLOMOUCI, Olomouc, CZ;
Abstract
Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.