The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 22, 2016

Filed:

Feb. 22, 2013
Applicant:

University of Medicine and Dentistry of New Jersey, Somerset, NJ (US);

Inventors:

Jeffrey D. Laskin, Piscataway, NJ (US);

Diane E. Heck, Rumson, NJ (US);

Geraldine Guillon, Macungie, PA (US);

Thomas Finetti, Livingston, NJ (US);

Angela Hunter, Mickleton, NJ (US);

Christophe Guillon, Macungie, PA (US);

Robert D. Rapp, Laurel Dale, PA (US);

Anna M. Vetrano, Hamilton, NJ (US);

Ned D. Heindel, Easton, PA (US);

Assignees:

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, New Brunswick, NJ (US);

LEHIGH UNIVERSITY, Bethlehem, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 249/14 (2006.01); C07D 249/12 (2006.01); A61K 31/42 (2006.01); C07D 409/04 (2006.01); C07D 405/04 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); A61K 31/4196 (2006.01);
U.S. Cl.
CPC ...
C07D 409/04 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); A61K 31/4196 (2013.01);
Abstract

Nitric oxide biosynthesis-inhibiting anti-inflammatory and anti-microbial compounds of Formula (3) and Formula (4) wherein R1 and R2 are independently selected from optionally substituted thienyl, optionally substituted furyl, optionally substituted —CH═CH-thienyl and optionally substituted —CH═CH-furyl, provided that R2 is substituted with as nitro group Treatment methods utilizing the compounds, and methods of synthesis of the compounds are also disclosed.


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