IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9289492 B1

PDFFull Text
Date of Patent:
Mar. 22, 2016

Filed:

Jul. 17, 2008

Collecting ovarian cancer stem cells from ovarian cancer cells

Applicants:

Patricia K Donahoe, Boston, MA (US);

Paul P Szotek, Indianapolis, IN (US);

David T Maclaughlin, Glouchester, MA (US);

Frederic Preffer, Cambridge, MA (US);

Rafael Pieretti-vanmarcke, Boston, MA (US);

David Michael Dombkowski, Cambridge, MA (US);

Inventors:

Patricia K Donahoe, Boston, MA (US);

Paul P Szotek, Indianapolis, IN (US);

David T MacLaughlin, Glouchester, MA (US);

Frederic Preffer, Cambridge, MA (US);

Rafael Pieretti-Vanmarcke, Boston, MA (US);

David Michael Dombkowski, Cambridge, MA (US);

Assignee:

The General Hospital Corporation, Boston, MA (US);

Attorney:

Nixon Peabody LLP

Primary Examiner:

Deborah Crouch

Assistant Examiner:

Magdalene Sgagias

Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 45/06 (2006.01); A61K 31/00 (2006.01); A61K 31/277 (2006.01); A61K 31/7088 (2006.01); C12N 5/095 (2010.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
A61K 45/06 (2013.01); A61K 31/00 (2013.01); A61K 31/277 (2013.01); A61K 31/7088 (2013.01); C12N 5/0695 (2013.01); G01N 33/5011 (2013.01); G01N 33/5091 (2013.01); G01N 33/57449 (2013.01); C12N 5/0672 (2013.01); C12N 2501/998 (2013.01); C12N 2503/00 (2013.01); C12N 2503/02 (2013.01); G01N 2800/44 (2013.01); G01N 2800/54 (2013.01);
Abstract

The present invention relates to compositions and methods for treating, characterizing and diagnosing ovarian cancer. In particular, the present invention provides methods for treating and/or preventing ovarian cancer in a subject by administering to the subject an effective amount of Mullerian Inhibiting substance and/or an effective amount of an agent that inhibits BCRP1. The present invention further provides methods to identify and/or enrich for populations of ovarian cancer stem cells and populations of somatic ovarian stem cells, in particular, enrichment for populations of coelomic somatic ovarian stem cells, subcoelomic/stromal somatic ovarian stem cells and periphilar medullary somatic ovarian stem cells. The present invention also provides somatic ovarian stem cell markers and ovarian cancer stem cell markers, as well as methods to identify agents which selectively inhibit the proliferation of ovarian cancer stem cells as compared to somatic ovarian stem cells.

Find Patent Forward Citations

Loading…