The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2016
Filed:
May. 28, 2013
Applicant:
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Inventor:
Masanori Aikawa, Chestnut Hill, MA (US);
Assignee:
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/18 (2006.01); C07K 16/22 (2006.01); C07K 14/705 (2006.01); C07K 14/435 (2006.01); C07K 14/475 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39533 (2013.01); C07K 14/705 (2013.01); A61K 39/395 (2013.01); A61K 48/00 (2013.01); A61K 2039/505 (2013.01); C07K 16/18 (2013.01); C07K 16/22 (2013.01); C07K 2316/96 (2013.01);
Abstract
The present invention is directed to methods of treating or preventing atherosclerosis and other cardiovascular diseases by administering agents that inhibit or modulate the NOTCH signaling pathway. In addition, the invention encompasses methods for assaying compounds for their ability to treat atherosclerosis based upon their effects on NOTCH signaling, and for measuring levels of amount, function, or activity of NOTCH pathway components in biological samples.