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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9289468 B1

PDFFull Text
Date of Patent:
Mar. 22, 2016

Filed:

Sep. 16, 2011

Fusion protein comprising circularly permuted form of trail/apo2l, coding gene and use thereof

Applicants:

Shifang Yang, Beijing, CN;

Junsheng Cui, Beijing, CN;

Bing Zhu, Beijing, CN;

Peng Wei, Beijing, CN;

Inventors:

Shifang Yang, Beijing, CN;

Junsheng Cui, Beijing, CN;

Bing Zhu, Beijing, CN;

Peng Wei, Beijing, CN;

Assignee:

Beijing Sunbio Biotech Co. Ltd., Beijing, CN;

Attorney:

Fitch, Even, Tabin & Flannery, LLP

Primary Examiner:

James H Alstrum Acevedo

Assistant Examiner:

Thea D' Ambrosio

Int. Cl.
CPC ...
A61K 38/16 (2006.01); A61K 38/12 (2006.01); A61K 38/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C07K 1/00 (2006.01); C07K 14/00 (2006.01); C07K 17/00 (2006.01); C07K 16/00 (2006.01); C12N 1/20 (2006.01); C12N 15/00 (2006.01); A61K 39/00 (2006.01); A61K 39/385 (2006.01); A61K 38/17 (2006.01); C07K 14/715 (2006.01); C07K 14/47 (2006.01); C07K 14/525 (2006.01); C12N 15/63 (2006.01); C12N 15/62 (2006.01); C07K 14/705 (2006.01); A61K 45/06 (2006.01); C07K 14/52 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1761 (2013.01); A61K 45/06 (2013.01); C07K 14/47 (2013.01); C07K 14/4747 (2013.01); C07K 14/52 (2013.01); C07K 14/525 (2013.01); C07K 14/70575 (2013.01); C07K 14/7151 (2013.01); C12N 15/62 (2013.01); C12N 15/63 (2013.01); A61K 38/00 (2013.01); C07K 2319/21 (2013.01); C07K 2319/33 (2013.01);
Abstract

Provided is a fusion protein comprising circularly permuted form of TRAIL, and the fusion protein contains circularly permuted form of TRAIL and oligopeptides located at the N-terminus and/or C-terminus of the permuted form. The oligopeptides contain a repeating sequence consisting of 3-10 histidines. The components of the circularly permuted form of TRAIL from N-terminus to C-terminus are: (a) amino acids 135-281 of TRAIL, (b) a linker, and (c) amino acids 121-135 of TRAIL or amino acids 114-135 of TRAIL or amino acids 95-135 of TRAIL or any fragments of amino acids 95-135 of TRAIL containing amino acids 121-135 of TRAIL. Also provided is a method for treating cancer by using the fusion protein.

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