The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2016
Filed:
Jun. 30, 2011
Christian Betzel, Schenefeld, DE;
Rolf Hilgenfeld, Luebeck, DE;
Dierk Hilterhaus, Kirchgellersen, DE;
Thomas Klupsch, Jena, DE;
Peter Muehlig, Jena, DE;
Karsten Dierks, Hamburg, DE;
Arne Meyer, Hamburg, DE;
Christian Betzel, Schenefeld, DE;
Rolf Hilgenfeld, Luebeck, DE;
Dierk Hilterhaus, Kirchgellersen, DE;
Thomas Klupsch, Jena, DE;
Peter Muehlig, Jena, DE;
Karsten Dierks, Hamburg, DE;
Arne Meyer, Hamburg, DE;
Xtal Concepts GmbH, Hamburg, DE;
Abstract
A method for crystallizing a substance dissolved in a solvent, including the following steps: introducing a solvent volume containing the substance into a chamber having a preset temperature, humidity, and gas composition, adding a predetermined volume of a precipitant to the solvent volume containing the substance, allowing the solvent to evaporate while simultaneously observing structural changes in the solvent volume containing the substance and the precipitant by means of dynamic light scattering, detecting weight changes and determining the molarities, making an association with the location in the phase diagram on the basis of the DLS measurement and the results of the molarity determination, allowing a predetermined number of crystal nuclei to form by adding solvent or adding precipitant, putting the solvent volume containing the substance and the precipitant into a metastable state by adding solvent and/or protein solution or by allowing the concentration of the dissolved substance to decrease by allowing nucleation cores to form, maintaining the metastable state by adding a predetermined amount of the substance to the solvent volume containing the substance and the precipitant or allowing the solvent to evaporate until at least one crystal of a predetermined size is formed.