The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 15, 2016

Filed:

Jul. 09, 2013
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Lee Josephson, Reading, MA (US);

Elisabeth Garanger, Bordeaux, FR;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/06 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); A61K 49/00 (2006.01); G01N 33/53 (2006.01); C12N 9/96 (2006.01); C07K 17/02 (2006.01); G01N 33/531 (2006.01); G01N 33/532 (2006.01);
U.S. Cl.
CPC ...
C07K 17/02 (2013.01); G01N 33/531 (2013.01); G01N 33/532 (2013.01);
Abstract

Multifunctional probes include a substrate (e.g., a nanoparticle, polymer, antibody, protein, low molecular weight compound, drug) and a multifunctional single-attachment-point (MSAP) reagent. The MSAP reagents can include three components: (i) a peptide scaffold, (ii) a single chemically reactive group on the peptide scaffold for reaction of the MSAP with a substrate having a complementary reactive group, and (iii) multiple functional groups on the peptide scaffold. The peptide scaffold can include any number of residues; however, for ease of synthesis and reproducibility in clinical trials, it is preferred to limit the residues in the peptide to 20 or less.


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