logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9284283 B1

PDFFull Text
Date of Patent:
Mar. 15, 2016

Filed:

Feb. 01, 2013

Macrocyclic compounds for modulating il-17

Applicant:

Ensemble Therapeutics Corporation, Cambridge, MA (US);

Inventors:

Michael Taylor, Lexington, MA (US);

Nicholas K. Terrett, Sherborn, MA (US);

William H. Connors, Lynnfield, MA (US);

Cheri Snedeker, Nashua, NH (US);

Kelley C. Shortsleeves, Maynard, MA (US);

Benjamin A. Seigal, Newton, MA (US);

Stephen P. Hale, Belmont, MA (US);

Timothy F. Briggs, Cambridge, MA (US);

Frank G. Favaloro, Jr., North Attleboro, MA (US);

Tyler J. Cipriani, North Stonington, CT (US);

Dingxue Yan, South Grafton, MA (US);

Sethu L. Alexander, Westford, MA (US);

Atli Thorarensen, Stow, MA (US);

Li Xing, Lexington, MA (US);

Assignee:

Ensemble Therapeutics Corporation, Cambridge, MA (US);

Attorney:

Goodwin Procter LLP

Primary Examiner:

Kristin Vajda

Int. Cl.
CPC ...
C07D 257/10 (2006.01); C07D 273/00 (2006.01); C07D 401/12 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 409/12 (2006.01); C07D 405/12 (2006.01); C07D 257/02 (2006.01); C07D 403/12 (2006.01); C07D 417/12 (2006.01); A61K 31/4965 (2006.01); A61K 31/33 (2006.01); A61K 31/44 (2006.01); A61K 31/445 (2006.01); A61K 31/425 (2006.01); A61K 31/42 (2006.01); A61K 31/38 (2006.01); A61K 31/35 (2006.01); A61K 38/00 (2006.01); A61K 31/366 (2006.01); C07D 255/02 (2006.01);
U.S. Cl.
CPC ...
C07D 257/10 (2013.01); A61K 31/366 (2013.01); A61K 31/42 (2013.01); A61K 38/00 (2013.01); C07D 255/02 (2013.01); C07D 257/02 (2013.01); C07D 273/00 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01);
Abstract

The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders.

Find Patent Forward Citations

Loading…