The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2016
Filed:
Mar. 26, 2012
Joung Han Yim, Gyeonggi-do, KR;
IL Chan Kim, Seoul, KR;
Dockyu Kim, Incheon, KR;
SE Jong Han, Gyunggi-do, KR;
Hyoung Seok Lee, Seoul, KR;
Hari Datta Bhattarai, Incheon, KR;
Tai Kyoung Kim, Incheon, KR;
Keun Sik Kim, Jeollanam-do, KR;
Joung Han Yim, Gyeonggi-do, KR;
Il Chan Kim, Seoul, KR;
Dockyu Kim, Incheon, KR;
Se Jong Han, Gyunggi-do, KR;
Hyoung Seok Lee, Seoul, KR;
Hari Datta Bhattarai, Incheon, KR;
Tai Kyoung Kim, Incheon, KR;
Keun Sik Kim, Jeollanam-do, KR;
KOREA INSTITUTE OF OCEAN SCIENCE AND TECHNOLOGY, Gyeonggi-Do, KR;
Abstract
Disclosed is a method of the synthesis of ramalin. It comprises reacting a glutamic acid derivative, which is prepared using alkylchloroformate, with a hydrazine salt compound, which is prepared from hydroxy aniline, whether protected or not. The synthesis method allows ramalin, excellent in antioxidant and anti-inflammatory activity, to be simply synthesized at stable yield even without use of a highly toxic solvent such as DMF. In addition, the method is cost competitive, and provides ramalin at high efficiency, thus enabling the mass production of ramalin.