The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 15, 2016

Filed:

Sep. 02, 2011
Applicants:

Brett A. Helms, San Francisco, CA (US);

Andrea R. Bayles, New Canaan, CT (US);

Inventors:

Brett A. Helms, San Francisco, CA (US);

Andrea R. Bayles, New Canaan, CT (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
B82Y 5/00 (2011.01); C08F 265/06 (2006.01); C08F 265/10 (2006.01); B82Y 15/00 (2011.01); G01N 33/50 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
B82Y 5/00 (2013.01); B82Y 15/00 (2013.01); C08F 265/06 (2013.01); C08F 265/10 (2013.01); G01N 33/5005 (2013.01); G01N 33/588 (2013.01);
Abstract

A facile procedure to deliver nanocrystals to the cytosol of live cells that is both rapid and general. The technique employs a unique cationic core-shell polymer colloid that directs nanocrystals to the cytosol of living cells within a few hours of incubation. The present methods and compositions enable a host of advanced applications arising from efficient cytosolic delivery of nanocrystal imaging probes: from single particle tracking experiments to monitoring protein-protein interactions in live cells for extended periods.


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