The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2016
Filed:
Aug. 14, 2008
Terrance Grant Johns, Clayton, AU;
Elizabeth Stockert, Vienna, AT;
Stephen Stockert, Vienna, AT;
Lloyd J. Old, New York, NY (US);
Andrew M. Scott, Kew East, AU;
Veronika M. Rayzman, Bentleigh, AU;
Terrance Grant Johns, Clayton, AU;
Elizabeth Stockert, Vienna, AT;
Lloyd J. Old, New York, NY (US);
Andrew M. Scott, Kew East, AU;
Veronika M. Rayzman, Bentleigh, AU;
Ludwig Institute for Cancer Research Ltd., New York, NY (US);
Abstract
The present invention relates to antibodies, particularly antibody 175, and fragments thereof or antibodies derived therefrom, which bind to the EGF receptor, particularly to amplified or overexpressed epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. These antibodies are useful in the diagnosis and treatment of cancer. Recombinant or hybrid antibodies having the variable region heavy or light chain sequence(s) of antibody 175 are also provided. The antibodies of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.