The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2016
Filed:
Sep. 14, 2012
James Andya, Millbrae, CA (US);
Jeffrey L. Cleland, San Carlos, CA (US);
Chung C. Hsu, Los Altos Hills, CA (US);
Xanthe M. Lam, South San Francisco, CA (US);
David E. Overcashier, Montara, CA (US);
Steven J. Shire, Emerald Hills, CA (US);
Janet Yu-feng Yang, San Mateo, CA (US);
Sylvia Sau-yan Wu, San Francisco, CA (US);
James Andya, Millbrae, CA (US);
Jeffrey L. Cleland, San Carlos, CA (US);
Chung C. Hsu, Los Altos Hills, CA (US);
Xanthe M. Lam, South San Francisco, CA (US);
David E. Overcashier, Montara, CA (US);
Steven J. Shire, Emerald Hills, CA (US);
Janet Yu-Feng Yang, San Mateo, CA (US);
Sylvia Sau-Yan Wu, San Francisco, CA (US);
GENENTECH, INC., South San Francisco, CA (US);
Abstract
A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.