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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9283218 B1

PDFFull Text
Date of Patent:
Mar. 15, 2016

Filed:

Dec. 12, 2013

Solid dispersion with improved solubility comprising tetrazole derivative as an active ingredient

Applicant:

Hanmi Pharm. Co., Ltd., Hwaseong-si, Gyeonggi-do, KR;

Inventors:

Yong Il Kim, Suwon-si, KR;

Jun Young Choi, Suwon-si, KR;

Young Keun Choi, Daegu, KR;

Jae Hyun Park, Suwon-si, KR;

Jong Soo Woo, Suwon-si, KR;

Assignee:

HANMI PHARM. CO., LTD, Hwaseong-si, KR;

Attorney:

Sughrue Mion, PLLC

Primary Examiner:

Raymond Henley, III

Int. Cl.
CPC ...
A61K 31/41 (2006.01); C07D 257/04 (2006.01); A61K 31/4725 (2006.01); C07D 405/14 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); A61K 45/06 (2006.01); A61K 31/337 (2006.01); A61K 31/475 (2006.01); A61K 31/704 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4725 (2013.01); A61K 31/337 (2013.01); A61K 31/475 (2013.01); A61K 31/704 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07B 2200/13 (2013.01);
Abstract

The present invention relates to an amorphous solid dispersion comprising a tetrazole derivative of the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. The solid dispersion of the present invention comprises a water-soluble polymer or an acid so as to improve the solubility of its active ingredient, i.e., the tetrazole derivative of the formula (I), thereby improving its absorption rate, and thus can be effectively used to reduce multi-drug resistance (MDR) in cancer cells.

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