The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 08, 2016

Filed:

Feb. 27, 2014
Applicant:

E. I. Du Pont DE Nemours and Company, Wilmington, DE (US);

Inventors:

Qiong Cheng, Wilmington, DE (US);

Stephen R. Fahnestock, Wilmington, DE (US);

Hongxian He, Wilmington, DE (US);

Kristy N. Kostichka, Wilmington, DE (US);

Hong Wang, Kennett Square, PA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/04 (2006.01); C07K 7/08 (2006.01); A61K 38/04 (2006.01); A61K 38/16 (2006.01); A61Q 5/00 (2006.01); A61K 47/48 (2006.01); C07K 14/00 (2006.01); G01N 33/68 (2006.01); G06F 19/16 (2011.01); A61K 8/64 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48338 (2013.01); A61K 8/64 (2013.01); A61Q 5/00 (2013.01); C07K 14/001 (2013.01); G01N 33/6803 (2013.01); G06F 19/16 (2013.01); C07K 2319/70 (2013.01);
Abstract

Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.


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