The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2016
Filed:
Aug. 08, 2013
Applicant:
Adocia, Lyons, FR;
Inventors:
Assignee:
ADOCIA, Lyons, FR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/18 (2006.01); A61K 47/16 (2006.01); A61K 39/395 (2006.01); C07K 16/22 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/186 (2013.01); A61K 39/395 (2013.01); A61K 39/39591 (2013.01); A61K 47/18 (2013.01); C07K 16/22 (2013.01); C07K 16/241 (2013.01); C07K 16/2887 (2013.01); A61K 9/0019 (2013.01);
Abstract
A process of lowering the viscosity of a solution includes preparing a solution comprising a compound of formula I, at a concentration in the final formulation of between 10 and 250 mM, and a protein having at least one antibody fragment whose concentration is between 50 and 350 mg/mL and whose pH is between 5 and 8. The compound lowers the viscosity of the solution, which is difficult to inject, by a value of at least 15% relative to the viscosity of a solution of at least one protein having at least one antibody fragment of the same concentration and of the same pH not containing the compound.