The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2016
Filed:
Oct. 27, 2014
University of Virginia Patent Foundation, Charlottesville, VA (US);
Timothy L. MacDonald, Charlottesville, VA (US);
Jerry L. Nadler, Charlottesville, VA (US);
Peng Cui, Charlottesville, VA (US);
UNIVERSITY OF VIRGINIA PATENT FOUNDATION, Charlottesville, VA (US);
Abstract
Phthalazine analogs of a Lisofylline (LSF) and synthetic methods for preparation of such analogs are provided. Compounds of the invention have structural formula III: wherein 1) Ris hydrogen and Ris selected from Calkyl, Calkenyl, or Calkynyl; or a pharmaceutically acceptable salt thereof; or 2) Ris hydrogen and Ris selected from Calkyl, Calkyl, Calkenyl, or Calkynyl; or a pharmaceutically acceptable salt thereof; or 3) Rand Rare the same or different and are selected from Calkyl, Calkyl, Calkenyl, or Calkynyl; or a pharmaceutically acceptable salt thereof. The analogs of LSF provided have the ability to protect cell viability, particularly the ability to protect pancreatic β-cells, to induce insulin secretion.