The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2016
Filed:
Oct. 20, 2009
Katalin Varadi, Vienna, AT;
Gerald Schrenk, Vienna, AT;
Hanspeter Rottensteiner, Vienna, AT;
Peter Turecek, Klosterneuburg, AT;
Alfred Weber, Vienna, AT;
Heinz Anderle, Klosterneuburg, AT;
Sean M. Culbertson, Gurley, AL (US);
Zhihao Fang, Madison, AL (US);
Harold Zappe, Harvest, AL (US);
Ping Zhang, Millbrae, CA (US);
Mary J. Bossard, Madison, AL (US);
Katalin Varadi, Vienna, AT;
Gerald Schrenk, Vienna, AT;
Hanspeter Rottensteiner, Vienna, AT;
Peter Turecek, Klosterneuburg, AT;
Alfred Weber, Vienna, AT;
Heinz Anderle, Klosterneuburg, AT;
Sean M. Culbertson, Gurley, AL (US);
Zhihao Fang, Madison, AL (US);
Harold Zappe, Harvest, AL (US);
Ping Zhang, Millbrae, CA (US);
Mary J. Bossard, Madison, AL (US);
BAXALTA INCORPORATED, Bannockburn, IL (US);
BAXALTA GMBH, Glattpark (Opfikon), CH;
NEKTAR THERAPEUTICS, San Francisco, CA (US);
Abstract
The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water-soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.