The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2016
Filed:
Jan. 09, 2009
Hiroyuki Aburatani, Tokyo, JP;
Shuichi Tsutsumi, Tokyo, JP;
Kunihiro Nishimura, Tokyo, JP;
Hirofumi Sakumoto, Tokyo, JP;
Shigeto Kawai, Tokyo, JP;
Hiroyuki Aburatani, Tokyo, JP;
Shuichi Tsutsumi, Tokyo, JP;
Kunihiro Nishimura, Tokyo, JP;
Hirofumi Sakumoto, Tokyo, JP;
Shigeto Kawai, Tokyo, JP;
THE UNIVERSITY OF TOKYO, Tokyo, JP;
CHUGAI SEIYAKU KABUSHIKI KAISHA, Tokyo, JP;
Abstract
The present invention relates to an antibody binding to Claudin6 (CLDN6) expressed on a cell membrane. The antibody of the present invention recognizes human CLDN6 present in a native form on cell membrane surface and exhibits cytotoxicity through ADCC and/or CDC activities against cancer cell lines highly expressing human CLDN6. Moreover, the antibody of the present invention has cell growth inhibitory effect through conjugation with toxin on cancer cell lines highly expressing human CLDN6. The human CLDN6 is overexpressed in tumor tissues (lung adenocarcinoma, gastric cancer, and ovarian cancer), although its expression is not observed in normal tissues. Thus, the anti-CLDN6 antibody is expected to highly accumulate in tumors highly expressing human CLDN6 and can serve as a very effective antitumor agent.