The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2016
Filed:
Mar. 21, 2014
The Johns Hopkins Unviersity, Baltimore, MD (US);
Institut National DE LA Santé ET DE LA Recherche Médicale, Paris, FR;
Gyanu Lamichhane, Towson, MD (US);
William R. Bishai, Towson, MD (US);
Radhika Gupta, Baltimore, MD (US);
Marie Lavollay, Bourg la Reine, FR;
Jean-Luc Mainardi, Chaville, FR;
Michel Arthur, Arcueil, FR;
The Johns Hopkins University, Baltimore, MD (US);
Institut National de la Sante et de la Recherche Medicale, Paris, FR;
Abstract
The peptidoglycan layer is a vital component of the bacterial cell wall, which comprises 4→3 and 3→3 transpeptide cross-linkages, the formation of which are catalyzed by D,D- and L,D-transpeptidases, respectively. Methods for the treatment of bacterial infections with agents that inhibit L,D-transpeptidases, either alone or in combination with D,D-transpeptidase inhibitors, are provided herein. Also provided are methods for the treatment of chronic stage tuberculosis with agents that inhibit enzyme with L,D-transpeptidase activity.