The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2016
Filed:
Feb. 28, 2013
Applicant:
Marc Ostermeier, Baltimore, MD (US);
Inventor:
Marc Ostermeier, Baltimore, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); C12N 15/64 (2006.01); C12N 15/74 (2006.01); C07H 21/04 (2006.01); C12N 15/63 (2006.01); C12N 15/10 (2006.01); C12N 15/62 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/635 (2013.01); C12N 15/1055 (2013.01); C12N 15/62 (2013.01); C12N 15/63 (2013.01); A61K 48/00 (2013.01); C07H 21/04 (2013.01); C07K 2319/02 (2013.01); C07K 2319/20 (2013.01); C07K 2319/24 (2013.01); C07K 2319/60 (2013.01); C07K 2319/70 (2013.01); C12N 15/64 (2013.01);
Abstract
The invention provides molecular switches which couple external signals to functionality and to methods of making and using the same. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, and modulate cell signaling pathways. Libraries comprising the switches and expression vectors and host cells for expressing the switches are also provided.