The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2016
Filed:
Aug. 24, 2010
Nathaniel G. Butlin, Pacifica, CA (US);
Kenneth N. Raymond, Berkeley, CA (US);
Jide Xu, Richmond, CA (US);
Anthony D'aleo, Berkeley, CA (US);
Nathaniel G. Butlin, Pacifica, CA (US);
Kenneth N. Raymond, Berkeley, CA (US);
Jide Xu, Richmond, CA (US);
Anthony D'Aleo, Berkeley, CA (US);
LUMIPHORE, INC., Berkeley, CA (US);
Abstract
The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.