IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9273014 B1

PDFFull Text
Date of Patent:
Mar. 01, 2016

Filed:

Feb. 20, 2015

Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof

Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Ashvinikumar V. Gavai, Princeton Junction, NJ (US);

George V. DeLucca, Pennington, NJ (US);

Daniel O'Malley, New Hope, NJ (US);

Patrice Gill, Levittown, NJ (US);

Claude A. Quesnelle, Skillman, NJ (US);

Brian E. Fink, Yardley, PA (US);

Yufen Zhao, Pennington, NJ (US);

Francis Y. Lee, Yardley, PA (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:

Gary D. Greenblatt

Primary Examiner:

Marcela M Cordero Garcia

Assistant Examiner:

Kaipeen Yang

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 47/00 (2006.01); C07D 243/24 (2006.01); A61K 31/5513 (2006.01); A61K 31/573 (2006.01); A61K 31/675 (2006.01); A61K 38/05 (2006.01); A61K 45/06 (2006.01); C07D 401/04 (2006.01); C07F 9/645 (2006.01); C07K 5/062 (2006.01); C07D 243/18 (2006.01); C07D 243/26 (2006.01); C07F 9/12 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 31/138 (2006.01); A61K 31/337 (2006.01); A61K 31/506 (2006.01); A61K 31/555 (2006.01); C07F 7/18 (2006.01); C07F 9/38 (2006.01); A61K 9/48 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
C07D 243/24 (2013.01); A61K 9/0019 (2013.01); A61K 9/0095 (2013.01); A61K 9/08 (2013.01); A61K 31/138 (2013.01); A61K 31/337 (2013.01); A61K 31/506 (2013.01); A61K 31/555 (2013.01); A61K 31/5513 (2013.01); A61K 31/573 (2013.01); A61K 31/675 (2013.01); A61K 38/05 (2013.01); A61K 45/06 (2013.01); C07D 243/18 (2013.01); C07D 243/26 (2013.01); C07D 401/04 (2013.01); C07F 7/1852 (2013.01); C07F 9/12 (2013.01); C07F 9/38 (2013.01); C07F 9/645 (2013.01); C07K 5/06052 (2013.01); A61K 9/4866 (2013.01); A61K 47/48246 (2013.01);
Abstract

Disclosed are compounds of Formula (I) and/or salts thereof: wherein Ris —CHCHCF; Ris —CHCHCFor —CHCHCHCF; Ris H, —CH, or R; Ris H or R; Ring A is phenyl or pyridinyl; and R, R, R, R, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer; or as prodrugs of such compounds.

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