The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 01, 2016

Filed:

Jan. 28, 2015
Applicants:

Shabana Usman Simjee, Karachi, PK;

Sabira Begum, Karachi, PK;

Saima Mahmood Malhi, Karachi, PK;

Huma Jawed, Karachi, PK;

Nadeem Ashraf, Karachi, PK;

Farina Hanif, Karachi, PK;

Bina S. Siddiqui, Karachi, PK;

Farhat Zubair, Karachi, PK;

Inventors:

Shabana Usman Simjee, Karachi, PK;

Sabira Begum, Karachi, PK;

Saima Mahmood Malhi, Karachi, PK;

Huma Jawed, Karachi, PK;

Nadeem Ashraf, Karachi, PK;

Farina Hanif, Karachi, PK;

Bina S. Siddiqui, Karachi, PK;

Farhat Zubair, Karachi, PK;

Assignee:

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 209/14 (2006.01); A61K 31/4045 (2006.01);
U.S. Cl.
CPC ...
C07D 209/14 (2013.01);
Abstract

The present invention evaluated the anti-epileptogenic effect of tryptamine derivative HHL-6 and its effects on the expression of BDNF and c-Fos. HHL-6 possesses potent anticonvulsant and anti-epileptic activity in PTZ-induced acute seizure and chemical kindling model of epilepsy. The results suggests that one of the possible mechanism of HHL-6 to inhibit epileptogenesis might be due to its controlling effect on the cellular and molecular expression of the factors that contribute in the development of epileptogenic plasticity in the CNS.


Find Patent Forward Citations

Simjee, Shabana. (2016). Modulation of c-fos and bdnf protein expression in pentylenetetrazole-kindled mice following the treatment with novel anti-epileptic compound hhl-6 (U.S. Patent No. 9272998). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9272998

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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