The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 01, 2016

Filed:

Jul. 21, 2011
Applicants:

Taichi Kusakabe, Chiba, JP;

Kennosuke Matsuda, Tokyo, JP;

Koichi Yamazaki, Tokyo, JP;

Tadaaki Ohgiya, Saitama, JP;

Kimiyuki Shibuya, Saitama, JP;

Inventors:

Taichi Kusakabe, Chiba, JP;

Kennosuke Matsuda, Tokyo, JP;

Koichi Yamazaki, Tokyo, JP;

Tadaaki Ohgiya, Saitama, JP;

Kimiyuki Shibuya, Saitama, JP;

Assignee:

Kowa Company, Ltd., Aichi, JP;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 22/08 (2006.01); C07C 22/04 (2006.01); C07C 17/16 (2006.01); C07C 17/04 (2006.01); C07B 53/00 (2006.01);
U.S. Cl.
CPC ...
C07C 17/04 (2013.01); C07B 53/00 (2013.01); C07C 17/16 (2013.01); C07C 22/08 (2013.01); C07B 2200/07 (2013.01);
Abstract

A method for preparing optically active 1-bromo-1-[3,5-bis(trifluoromethyl)-phenyl]ethane having a high optical purity, which comprises the step of brominating optically active 1-[3,5-bis(trifluoromethyl)phenyl]ethanol by using, as a brominating agent, (a) a combination of a phosphorus halide and hydrogen bromide, (b) a combination of 1,2-dibromo-1,1,2,2-tetrachloroethane and an organic phosphorous compound represented by the general formula (I): P(R)(R)(R) (in the formula, R, R, and Rindependently represent a Caryl group, a Caryloxy group, a Calkyl group, a Calkoxyl group, a Ccycloalkyl group, or a Ccycloalkoxy group), or (c) a combination of N-bromosuccinimide and a dialkyl sulfide.


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