The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 01, 2016

Filed:

Sep. 08, 2014
Applicant:

The United States of America As Represented BY the Secretary of the Air Force, Washington, DC (US);

Inventors:

Thomas J Lamkin, Fairfield, OH (US);

Roland Saldanha, Dayton, OH (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/02 (2006.01); A61K 49/00 (2006.01); A61K 48/00 (2006.01); C12N 15/74 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0208 (2013.01); C12N 15/74 (2013.01); A61K 2039/522 (2013.01);
Abstract

The present invention includes live strain ofwherein a gene selected from the group consisting of priA and purA is inactivated. The present invention further includes a pharmaceutical composition comprising one or more live strains ofaccording to the present invention and a pharmaceutically acceptable carrier. The present invention further includes a method of using one or more live strains ofaccording to the present invention to confer immunity against a virulent strain of. The method comprises administering an effective amount of one or more live strains ofaccording to the present invention or a pharmaceutical composition comprising one or more livestrains to an animal such that an immune response is produced in the animal.


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