The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2016
Filed:
Sep. 10, 2010
Applicant:
Yang-xin Fu, Chicago, IL (US);
Inventor:
Yang-Xin Fu, Chicago, IL (US);
Assignee:
The University of Chicago, Chicago, IL (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); A61K 39/00 (2006.01); C07K 14/525 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0011 (2013.01); C07K 14/525 (2013.01); C12N 7/00 (2013.01); A61K 2039/5152 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5256 (2013.01); A61K 2039/53 (2013.01); C07K 2319/43 (2013.01); C12N 2710/10043 (2013.01); C12N 2799/022 (2013.01);
Abstract
Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and eradication of metastasis using mutant LIGHT are disclosed.