The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2016
Filed:
May. 16, 2012
Daniel Leblanc, Geneva, CH;
Evert Nicolaas Lamme, Nyon, CH;
Helen Gabriela Baldascini, Rome, IT;
Joel Richard, Mere, FR;
Frederic Checot, Taluyers, FR;
You-ping Chan, Ternay, FR;
Roger Kravtzoff, Algans, FR;
Gauthier Pouliquen, Ternay, FR;
Daniel Leblanc, Geneva, CH;
Evert Nicolaas Lamme, Nyon, CH;
Helen Gabriela Baldascini, Rome, IT;
Joel Richard, Mere, FR;
Frederic Checot, Taluyers, FR;
You-Ping Chan, Ternay, FR;
Roger Kravtzoff, Algans, FR;
Gauthier Pouliquen, Ternay, FR;
ARES TRADING S.A., Aubonne, CH;
Abstract
The present invention pertains to interferon-beta (IFN-beta) compositions comprising interferon-beta and a grafted poly(glutamic acid) polymer having an average molecular weight between 26,000 and 40,000 g/mol, grafted with alpha-tocopherol substituents, the average molar grafting ratio being 4.5-5.5 moles %, the weight/weight ratio between said grafted poly(glutamic acid) polymer and IFN-beta being between 24 and 125. The present invention also pertains to the preparation methods of such compositions and their application to obtain therapeutic compositions in dosage unit form delivering IFN-beta over an extended period of time.