The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 01, 2016

Filed:

Apr. 18, 2012
Applicants:

Hirohito Tsubouchi, Kyoto, JP;

Akio Ido, Kyoto, JP;

Tsutomu Chiba, Kyoto, JP;

Akira Shimizu, Kyoto, JP;

Inventors:

Hirohito Tsubouchi, Kyoto, JP;

Akio Ido, Kyoto, JP;

Tsutomu Chiba, Kyoto, JP;

Akira Shimizu, Kyoto, JP;

Assignee:

Kyoto University, Kyoto, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); C07K 14/475 (2006.01); A61K 39/395 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1833 (2013.01); A61K 39/3955 (2013.01); C07K 14/4753 (2013.01); G01N 33/6893 (2013.01); G01N 2800/085 (2013.01); G01N 2800/52 (2013.01);
Abstract

The present invention provides a therapeutic agent for acute liver failure containing a hepatocyte growth factor (HGF), particularly an agent for treating fulminant hepatitis or late onset hepatic failure or suppression of progression of acute liver failure without hepatic coma to fulminant hepatitis or late onset hepatic failure. The present invention also provides a method for evaluating the efficacy of HGF including measuring the amount of α-fetoprotein (liver regeneration biomarker) and/or soluble Fas (anti-apoptotic biomarker) in a sample obtained from a liver injury patient administered with HGF.


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