IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9266872 B1

PDFFull Text
Date of Patent:
Feb. 23, 2016

Filed:

Apr. 18, 2014

2-hydroxyarylamide derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient

Applicant:

Korea Research Institute of Bioscience and Biotechnology, Daejeon, KR;

Inventors:

Semi Kim, Daejeon, KR;

Ill Young Lee, Daejeon, KR;

Hye-Jin Min, Daejeon, KR;

Eun-Hee Nam, Daejeon, KR;

Pilho Kim, Daejeon, KR;

Chang Soo Yun, Daejeon, KR;

Dong Joon Ko, Daejeon, KR;

Assignee:

Korea Research Institute of Bioscience and Biotechnology, , KR;

Attorney:

Sheridan Ross P.C.

Primary Examiner:

Deepak Rao

Int. Cl.
CPC ...
A61K 31/167 (2006.01); A61K 31/426 (2006.01); C07D 417/04 (2006.01); C07D 215/38 (2006.01); C07D 285/135 (2006.01); C07D 213/75 (2006.01); C07D 239/42 (2006.01); C07D 277/46 (2006.01); C07D 213/82 (2006.01); C07D 215/56 (2006.01); C07D 277/82 (2006.01); A61K 31/4439 (2006.01); A61K 31/428 (2006.01); A61K 31/433 (2006.01); A61K 31/44 (2006.01); A61K 31/4709 (2006.01); A61K 31/505 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
C07D 417/04 (2013.01); A61K 31/167 (2013.01); A61K 31/426 (2013.01); A61K 31/428 (2013.01); A61K 31/433 (2013.01); A61K 31/44 (2013.01); A61K 31/4439 (2013.01); A61K 31/4709 (2013.01); A61K 31/505 (2013.01); A61K 31/5377 (2013.01); C07D 213/75 (2013.01); C07D 213/82 (2013.01); C07D 215/38 (2013.01); C07D 215/56 (2013.01); C07D 239/42 (2013.01); C07D 277/46 (2013.01); C07D 277/82 (2013.01); C07D 285/135 (2013.01);
Abstract

The present invention relates to a 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The 2-hydroxyarylamide derivative prepared by the present invention is excellent in the inhibition of the activity of TMPRSS4 serine protease and the suppression of the infiltration of TMPRSS4-expressed cancer cells, and thus can be useful as a composition for preventing or treating cancer by inhibiting TMPRSS4 over-expressed in cancer cells, particularly, colorectal cancer, lung cancer, breast cancer, prostate cancer, ovarian cancer, pancreatic cancer, or stomach cancer cells.

Find Patent Forward Citations

Loading…