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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9266840 B1

PDFFull Text
Date of Patent:
Feb. 23, 2016

Filed:

Oct. 17, 2012

Bicyclic heterocyclic compound

Applicant:

Astellas Pharma Inc., Tokyo, JP;

Inventors:

Shimpei Kawakami, Tokyo, JP;

Minoru Sakurai, Ibaraki, JP;

Noriyuki Kawano, Ibaraki, JP;

Takayuki Suzuki, Tokyo, JP;

Nobuyuki Shiraishi, Tokyo, JP;

Wataru Hamaguchi, Tokyo, JP;

Ryuichi Sekioka, Tokyo, JP;

Hiroyuki Moritomo, Tokyo, JP;

Ayako Moritomo, Tokyo, JP;

Assignee:

ASTELLAS PHARMA INC., Tokyo, JP;

Attorney:

Oblon, McClelland, Maier & Neustadt, L.L.P

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
C07D 417/14 (2006.01); C07D 239/80 (2006.01); C07D 401/12 (2006.01); C07D 237/28 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 231/56 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 237/28 (2013.01); C07D 231/56 (2013.01); C07D 239/80 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01);
Abstract

To provide a compound useful as an active ingredient of a pharmaceutical composition for treating 11β-hydroxysteroid dehydrogenase type 1-related diseases such as dementia, schizophrenia, depression, pain (particularly, neuropathic pain or fibromyalgia), diabetes (particularly, type II diabetes mellitus), insulin resistance and the like. [Means for Solution] A bicyclic heterocyclic compound (the bicyclic heterocycle is formed when a cyclohexane ring is fused with a 5- to 6-membered monocyclic heterocycle that has only a nitrogen atom as a hetero atom) substituted with an acylamino group such as a (hetero)aroylamino group or the like or a pharmaceutically acceptable salt thereof was found to have an excellent selective inhibitory action against 11β-HSD1. Accordingly, the bicyclic heterocyclic compound of the present invention can be used for treating dementia, schizophrenia, depression, pain (particularly, neuropathic pain or fibromyalgia), diabetes (particularly, type II diabetes mellitus), insulin resistance, and the like.

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