The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 23, 2016

Filed:

Jul. 21, 2014
Applicant:

Emory University, Atlanta, GA (US);

Inventor:

Keqiang Ye, Lilburn, GA (US);

Assignee:

Emory University, Atlanta, GA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/05 (2006.01); A61K 31/12 (2006.01); A61K 31/133 (2006.01); A61K 31/135 (2006.01); C07C 225/16 (2006.01); C07C 215/60 (2006.01); C07C 237/20 (2006.01); A61K 31/137 (2006.01);
U.S. Cl.
CPC ...
C07C 225/16 (2013.01); A61K 31/05 (2013.01); A61K 31/12 (2013.01); A61K 31/133 (2013.01); A61K 31/135 (2013.01); A61K 31/137 (2013.01); C07C 215/60 (2013.01); C07C 237/20 (2013.01);
Abstract

Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing a catecholamine backbone and pharmaceutically acceptable salts, prodrugs, and derivatives thereof. Specifically, methods, compositions, and compounds for the treatment of disorders including neurological disorders, neuropsychiatric disorders, and metabolic disorders are provided. For example, a first method is provided of treating or reducing the risk of depression, anxiety, or obesity in a subject, which includes administering to the subject a therapeutically effective amount of the described compounds. A further method of promoting neuroprotection in a subject also is provided, which includes administering to the subject a therapeutically effective amount of the described compounds.


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