The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 23, 2016

Filed:

Feb. 01, 2012
Applicants:

Stanley Hazen, Pepper Pike, OH (US);

Zeneng Wang, Shaker Heights, OH (US);

Inventors:

Stanley Hazen, Pepper Pike, OH (US);

Zeneng Wang, Shaker Heights, OH (US);

Assignee:

THE CLEVELAND CLINIC FOUNDATION, Cleveland, OH (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/045 (2006.01); A61K 31/43 (2006.01); A61K 31/496 (2006.01); A61K 31/14 (2006.01); A61K 31/4164 (2006.01); A61K 31/7048 (2006.01); A23L 2/52 (2006.01); A23L 1/30 (2006.01);
U.S. Cl.
CPC ...
A61K 31/045 (2013.01); A23L 1/30 (2013.01); A23L 2/52 (2013.01); A61K 31/14 (2013.01); A61K 31/4164 (2013.01); A61K 31/43 (2013.01); A61K 31/496 (2013.01); A61K 31/7048 (2013.01);
Abstract

Provided herein are compositions for the treatment and/or prevention of cardiovascular disease (CVD), and methods of application and use thereof. In particular, the present invention provides treatment and/or prevention of cardiovascular disease with 3,3-dimethyl-1-butanol (DMB) and related compounds, and pharmaceutical formulations thereof. In other embodiments, the present invention provides methods of administering a gut flora targeting antibiotic to a subject prior to a procedure that is associated with a risk of causing thrombosis, heart-attack, and/or platelet hyper-responsiveness.


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