The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2016
Filed:
Oct. 26, 2011
Dipak Kalita, Andhra Pradesh, IN;
Mohosin Layek, West Bengal, IN;
Atmakuri Venkata Dhanunjaya Rao, Andhra Pradesh, IN;
Venkat Aravinda Potula, Andhra Pradesh, IN;
Vikas Gajare, Andhra Pradesh, IN;
Kesavan Balakumaran, Andhra Pradesh, IN;
Anders Nilsson, Lund, SE;
Guangcheng Jiang, San Diego, CA (US);
Dipak Kalita, Andhra Pradesh, IN;
Mohosin Layek, West Bengal, IN;
Atmakuri Venkata Dhanunjaya Rao, Andhra Pradesh, IN;
Venkat Aravinda Potula, Andhra Pradesh, IN;
Vikas Gajare, Andhra Pradesh, IN;
Kesavan Balakumaran, Andhra Pradesh, IN;
Anders Nilsson, Lund, SE;
Guangcheng Jiang, San Diego, CA (US);
Ferring B.V., HHoofddorp, NL;
Abstract
The present invention relates to a liquid (or solution)-phase manufacturing process for preparing the decapeptide Degareiix, its amino-protected precursor, and other useful intermediates. The invention further relates to polypeptides useful in the solution-phase manufacturing process and to the purification of Degareiix itself. The manufacturing process comprises the step of cleaving the ε-amino protecting group Pε from a Degareiix precursor according to formula {P)(Pε)Ac-AA-AA-NHin an organic solvent comprising the precursor and a cleaving agent dissolved therein: wherein Pis a hydroxyl-protecting group or hydrogen, preferably hydrogen.