The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 16, 2016

Filed:

Sep. 30, 2014
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Scott Wolkenberg, Jenkintown, PA (US);

Scott T. Harrison, Glenside, PA (US);

James C. Barrow, Arnold, MD (US);

Zhijan Zhao, Hatfield, PA (US);

Jeffrey Melamed, North Wales, PA (US);

Nathan R. Kett, Franklin, TN (US);

Amy Zartman, West Point, PA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); C07D 401/14 (2006.01); C07D 239/54 (2006.01); C07D 239/553 (2006.01); C07D 401/10 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 45/06 (2013.01); C07D 239/54 (2013.01); C07D 239/553 (2013.01); C07D 401/10 (2013.01);
Abstract

The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.


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