The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2016
Filed:
Sep. 13, 2012
Johannes Aebi, Binningen, CH;
Kurt Amrein, Itingen, CH;
Benoit Hornsperger, Altkirch, FR;
Henner Knust, Rheinfelden, DE;
Bernd Kuhn, Reinach BL, CH;
Yongfu Liu, Shanghai, CN;
Hans P. Maerki, Basel, CH;
Alexander V. Mayweg, Shanghai, CN;
Peter Mohr, Basel, CH;
Xuefei Tan, Shanghai, CN;
Mingwei Zhou, Shanghai, CN;
Johannes Aebi, Binningen, CH;
Kurt Amrein, Itingen, CH;
Benoit Hornsperger, Altkirch, FR;
Henner Knust, Rheinfelden, DE;
Bernd Kuhn, Reinach BL, CH;
Yongfu Liu, Shanghai, CN;
Hans P. Maerki, Basel, CH;
Alexander V. Mayweg, Shanghai, CN;
Peter Mohr, Basel, CH;
Xuefei Tan, Shanghai, CN;
Mingwei Zhou, Shanghai, CN;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The invention provides novel compounds having the general formula (I) wherein R, R, R, R, R, R, R, A, Aand Aare as described herein, compositions including the compounds and methods of using the compounds. These compounds are useful for therapy or prophylaxis in a mammal, and in particular as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.